Introduction: Hemophilia is an inherited bleeding disorder that is sex-linked. Hemophilia have an impact on many aspects of patient and family life. Because of this, need a comprehensive care program and case management.

Aim: The evaluation of effect case management program by nurses on quality of life of pre-school children with hemophilia.

Method: A semi experimental research was performed at comprehensive hemophilia treatment center during the year 2011-2012.With attention to characteristics of sample 52 pre-school children with hemophilia selected and were randomly divided in two groups (26 case &26 control).The data collecting tools included the questionnaire of demographic characteristics, hemophilia children’s quality of life (Haemo - Qol).Validity and reliability of the questionnaire were assessed by content validity and alfa-chronbach methods. Quality of life in both groups were assessed before and3months after the intervention in case group. After collecting the pre-intervention data,case management program was performed on the case group based on the five steps of case management process (assessment & problem identification,case plan, implementation,evaluation & follow-up).The data were analyzed using spss16.

Results: Test of Chi-Squared revealed that two groups had no significant differences in terms of demographic characteristics (p>0.05). Independent t-test showed that the quality of life total score before intervention hasn’t got a significant difference between two groups (p=0.34). While after intervention the same test indicated a significant difference between the two groups (p=0.00).Paired t-test showed that the quality of life total score before and after intervention in the case group has a significant difference (p=0.00)and the same test hasn’t significant difference in the control group (p=0.26).

Conclusion: The findings of study showed that organization,clarity of roles,and follow-up using coordination,management and care roles of nursing result in increased hemophilic children and their parent’s quality of life and it is suggested that in care of patients with hemophilia, this program is applied.