Introduction: Nursing managers are deciding under uncertainty permanently because of their professional nature and confronting with critical conditions so, their decisions are associated with a high risk that can cause serious harm to patients and profession. So, it would be important identifying effective factors on decreasing uncertainty in their decision-making. Aim: This study aimed to determine the amount of uncertainty in decision-making among nurse managers and its relationship with some their job characteristics in 2014 in hospitals in Dezful province. Methods and Materials: This study was cross - sectional that it was done on nursing directors, supervisors and the head nurses. Method of sampling was census and (65) nurse managers participated in study. Data gathered by questionnaires job characteristics and uncertainty in decision-making. Content validity was used and test-retest for assessing its reliability (0/95).ِData analyzed under SPSS20 with descriptive and analytical statistics tests (Mann Whiteny, Pearson and Kroscal-Wallis). Results: Findings showed that uncertainty rate in most nursing directors (67.7 percent), was at its minimum rate, and a significant correlation was found between uncertainty rate in decision-making and managerial experiences negatively, (p= 0.03, r= -0.241) while the there was no correlation between others’ characteristics of job. Conclusion: regarding the relationship between uncertainty in decision- making and managerial experiences, it would be suggested for improving decision- making in uncertainty situations, young managers work with experienced managers together and also inservice education would be useful.