Introduction: Always clinical nurses are in healthy risk, because of their work identity. Nurses who are not healthy in physical and
psychological domains they could not delivery nursing care to
patients.

Aim: This study was done to identify factors associated with
depression and quality of life nurses who worked in Ilam city
hospitals.

Method: This was a cross-sectional study that was done for all
nurses who were working in Ilam city hospitals in 2011. Data
gathering was done by BDI= Beck Depression Inventory, Short form-QOL12 and demographic questionnaire. Path analysis as a
statistical method was used to test the causal model. For path
analysis depression and quality of life, a hypothetical causal model designed, so was used of regression multivariate analysis and was
obtained final model of the depression and quality of life. In this study
depression variable was independent variable and the others were independent variables and also, SPSS18 software used for data
analysis.

Results: According to path analysis, important related variables with depression were respectively, mental domain QOL (28%),
married status(25%), physical domain QOL(24%), shift
working (18%), age (16%), and overtime hours working (12%), that direct effect of these variables were more than indirect effect through of mental and physical domains of nurses’ QOL on their depression .Also, in this model depression variables and QOL could be predicted (48%) variance depression to other variables.

Conclusion: Nurse managers must be planning to increase nurses’ mental health, attention to variety aspects of family such as marriage, decrease and distribution of times working especially in night shift could be increased quality of life in nurses and decreased their
depression.