Background: Organization environment obligates managers to choose proper leadership style that it matched with the current situation and their own and subordinates' personality types, it is resulted to increase efficiency and effectiveness of the organization. Aim: This study analyze the relationship between leadership style and personality characteristics of nurse managers in educational hospitals that affiliated to Hamadan University of Medical Sciences.. Method: In this correlational study all nurse managers were selected (90) in educational hospitals that affiliated to Hamadan University of Medical Sciences.in 2013 in Hamedan city. Data collected with a self- reported questionnaires for leadership style "describing the effectiveness and flexibility LEAD- Self" and the other with 60 questions was " NEO" for assessing personality.They were standards tool that their reliability were (r=0.92) and (r=0.68) for NEO. Data were analyzed with statistics tests(2 and t-independent ) and &alpha=<0/05. Results: findings showed that the majority of nurse managers had selling leadership style (52.2%). Also, there was a significant positive relationship between the extrovert- introversion personality and leadership style (p=0/030), but there was no significant relationship between leadership style and neuroticism, flexibility, agreeableness and conscientiousness personality (p &ge0/05). Conclusion: based on nurse managers' personality, it would be suggested that they prepare for applying participative style.